/OPR:REF and /OPT:NOICF should be set when you set debug = true for a profile. Similarly, /INCREMENTAL:NO should be set when incremental = false.
Unfortunately, by default /FIXED:NO only applies for DLLs. The only option I have is to manually pass linker options to rustc at this point (either /PROFILE or /FIXED:NO).
How can you pass linker options to a cargo build command?